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| Registros recuperados: 31.147 | |
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| Sá,Matheus Malta de; Pasqualoto,Kerly Fernanda Mesquita; Rangel-Yagui,Carlota de Oliveira. |
| Drugs acting on the central nervous system (CNS) have to cross the blood-brain barrier (BBB) in order to perform their pharmacological actions. Passive BBB diffusion can be partially expressed by the blood/brain partition coefficient (logBB). As the experimental evaluation of logBB is time and cost consuming, theoretical methods such as quantitative structure-property relationships (QSPR) can be useful to predict logBB values. In this study, a 2D-QSPR approach was applied to a set of 28 drugs acting on the CNS, using the logBB property as biological data. The best QSPR model [n = 21, r = 0.94 (r² = 0.88), s = 0.28, and Q² = 0.82] presented three molecular descriptors: calculated n-octanol/water partition coefficient (ClogP), polar surface area (PSA), and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Two-dimensional quantitative structure-property relationships (2D-QSPR); Calculated n-octanol/water partition coefficient (ClogP); Blood-brain barrier; Benzodiazepines. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400016 |
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| Huret, Martin; Petitgas, Pierre; Struski, Caroline; Leger, Fabien; Sourisseau, Marc; Lazure, Pascal. |
| Overexploitation and climate change are increasingly causing unanticipated changes in marine ecosystems, such as higher variability in fish recruitment and shifts in species distribution, pressing for developing fisheries oceanography. In the meantime, operational oceanography rapidly progresses and its products become easy to access to a large community, among them fisheries scientists. Multiyear oceanographic reanalyses (hindcasts) were identified has a priority product by the ICES WG on Operational Oceanographic Products for Fisheries and Environment (WGOOFE). We performed a 37 years hindcast (1972-2008) run with a coupled physical-biogeochemical model (ECO-MARS3D) over the Bay of Biscay, using realistic meteorological and run-off forcing. We first... |
| Tipo: Text |
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| Ano: 2010 |
URL: http://archimer.ifremer.fr/doc/00023/13432/10442.pdf |
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| GASQUES, J. G.; VIEIRA FILHO, J. E. R.; NAVARRO, Z.. |
| Primeira parte: Desempenho produtivo e estrutura. Cap. 1 - Produtividade total dos fatores e transformações da agricultura brasileira: análise dos dados dos censos agropecuários; Cap. 2 - Evolução recente da estrutura fundiária e propriedade rural no Brasil. Segunda parte: Mudança tecnológica e especificidades setoriais. Cap. 3 Trajetória tecnológica e aprendizado no setor agropecuário; Cap. 4 - Inovação tecnológica na agricultura, o papel da biotecnologia agrícola e a emergência de mercados regulados; Cap. 5 - Mudanças e reiteração da heterogeneidade do mercado de trabalho agrícola. terceira parte: Segmentações sociais e disputas sociopolíticas. Cap. 6 - Os desafios das agriculturas brasileiras; Cap. 7 - A agricultura familiar no Brasil: entre a política... |
| Tipo: Livro técnico (INFOTECA-E) |
Palavras-chave: Produtividade agrícola; Desenvolvimento rural. |
| Ano: 2010 |
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/904332 |
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| Carmo,Renato Miguel do. |
| Em Portugal, as ciências sociais têm estudado a agricultura familiar a partir de um modelo de interpretação dualista que acentua as diferenças inter-regionais, marginalizando, até certo ponto, o significado sociológico de algumas continuidades que se estabeleciam (e se estabelecem) entre as zonas do Norte e do Sul ou entre o Litoral e o Interior. O presente estudo pretende, assim, construir uma perspectiva diferente sobre as modalidades de agricultura familiar em Portugal, procurando identificar, num primeiro momento, uma série de proximidades sociológicas entre os diferentes modos de organização (tradicionais e modernos) das famílias agrícolas e, consequentemente, traçar os eixos para um modelo mais complexo na análise dessas mesmas modalidades. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rural; Pluriactividade; Agricultura familiar; Portugal. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-20032010000100001 |
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| Silva,M.L.; Martins,B.C.; Ribeiro,A.P.; Souza,A.L. Groszewicz de; Laus,J.L.. |
| A- and B-modes ultrasonographic changes in the thickness of various structures of the eyeball in male and female English Cocker Spaniel dogs with and without nondiabetic cataracts were evaluated. Sixteen dogs with cataracts (32 eyes) and seven normal dogs (14 eyes) older than eight years were selected. A- and B-modes ultrasonography was performed with a 10MHz transducer. Data was statistically evaluated by one way ANOVA. Mean and standard deviations of various ocular structures for dogs with and without cataracts were, respectively, anterior chamber: 3.041±0.828mm, 3.373±1.040mm; lens: 6.817±1.117mm, 7.062±0.477mm; vitreous: 10.056±0.754mm, 9.523±0.705mm; and axial length: 19.909±1.103mm, 19.958±1.050mm. Ocular measurements between right and left eyes,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dog; Ultrasonography; Cataract. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000500009 |
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| Xuri Wu; Nan Liu; Yunmian He; Yijun Chen. |
| Various ketoreductases exclusively participate in all common biological events, and they are a class of important biocatalysts for the production of chiral alcohols. While many types of ketoreductase have been extensively studied and their functions, properties and utilities have been well known, the capability of stereoselectively reducing two carbonyl groups in the same diketohexanoate ester molecule to form a dihydroxy product by a single ketoreductase has not been evidently characterized. Here we show that a unique and novel enzyme, diketoreductase, was cloned from Acinetobacter baylyi, heterogeneously expressed in _Escherichia coli_ and purified to homogeneity. The diketoreductase is up to 78% homologous to bacterial 3-hydroxyacyl coenzyme-A... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Chemistry; Microbiology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/1697/version/2 |
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| Nabradi, Andras; Szollosi, Laszlo. |
| A helyzetfelmérés eredményeként megállapítható, hogy a magyar baromfi ágazat legfőbb problémája a nemzetközi versenyképesség romlása. Ennek számos következménye lehet, ami közvetlenül vagy közvetve érinti a fenntarthatóság három pillérét, a gazdasági, társadalmi és természeti tényezőket. Az elemzésben feltárt problémák ok-okozati kapcsolataiból egyértelműen kiderül, hogy mindezt az ágazat hazai és nemzetközi piaci kiszolgáltatottságának növekedése, valamint az ágazatban tapasztalható objektív versenyhátrányok megléte okozta. Ez utóbbi a versenytársakhoz képest tartósan alacsony jövedelmezőségnek, a technológiai színvonalban tapasztalható lemaradásnak, a korszerű tudás, illetve az ágazati stratégia hiányának tulajdonítható. A főbb problémakörökre... |
| Tipo: Journal Article |
Palavras-chave: Poultry sector; Problem-tree; Goal-structure; International competitiveness; Market defencelessness; Competitive disadvantages; Agribusiness; Livestock Production/Industries; Production Economics; Baromfi ágazat; Problémafa; Célstruktúra; Nemzetközi versenyképesség; Versenyhátrányok. |
| Ano: 2008 |
URL: http://purl.umn.edu/58605 |
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| Hoshino, Eriko; CSIRO Oceans and Atmosphere, Hobart, TAS, Australia; Tasmanian School of Business and Economics, University of Tasmania, Hobart, TAS, Australia; eriko.hoshino@csiro.au; van Putten, Ingrid; CSIRO Oceans and Atmosphere, Hobart, TAS, Australia; Centre for Marine Socioecology, University of Tasmania, Hobart, TAS, Australia; Ingrid.vanputten@csiro.au; Girsang, Wardis; Faculty of Agriculture, University of Pattimura, Ambon, Indonesia; girsang_2010@yahoo.com; Resosudarmo, Budy P; Indonesia Project, Arndt-Corden Department of Economics, Crawford School of Public Policy, Australian National University, ACT, Australia; budy.resosudarmo@anu.edu.au; Yamazaki, Satoshi; Tasmanian School of Business and Economics, University of Tasmania, Hobart, TAS, Australia; Centre for Marine Socioecology, University of Tasmania, Hobart, TAS, Australia; satoshi.yamazaki@utas.edu.au. |
| Understanding the specific relationships between ecological and socioeconomic conditions and marine tenure is likely to contribute to successful functioning of self-governance institutions for common-pool resources. Complex interrelationships of factors influencing fishing activities of coastal communities and implementation of customary marine tenure over their waters can be represented in a Bayesian belief network model. We developed a Bayesian belief network model that includes the links between factors for fishing communities in the Kei Islands in Indonesia, based on indepth local surveys. Our results showed that the cumulative impacts of multiple factors on key social, economic, and environmental outcomes can be much larger than the impact from a... |
| Tipo: Peer-Reviewed Reports |
Palavras-chave: Bayesian belief network; Community-based management; Customary marine tenure; Indonesia; Small-scale fisheries; Social-ecological systems. |
| Ano: 2016 |
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| Harvey, Sallyann; Fisher, Bill; Larson, Kristoffer; Malcolm, Bill. |
| The Queensland Fruit Fly (QFF) — Bactrocera tryoni — poses a significant threat to horticultural production in Victoria causing losses of fruit and jeopardising access to interstate and international markets. The Victorian Government implements and largely funds an area freedom program to manage QFF. Concern about the record number of outbreaks in 2007-08 and the escalating costs of maintaining the current management regime, led the Victorian Department of Primary Industries to review the program to identify improved strategies for managing QFF. As part of this work, a benefit cost analysis (BCA) of alternative strategies has been conducted. While the BCA method is well established, in general few studies are publicly available for area freedom programs.... |
| Tipo: Conference Paper or Presentation |
Palavras-chave: International Relations/Trade. |
| Ano: 2010 |
URL: http://purl.umn.edu/59740 |
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| Registros recuperados: 31.147 | |
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